No. Any kind of strange things are supposed to happen because of a wrong configuration - that's not weird, that's quite normal. :)
Make friends with your error_log file, and you'll find a lot of useful information - like unaccessable directories - giving you the right idea about the reason of your problem and how to solve it.
Aside from that: Have in mind that other members are waiting for answers, too. Stay fair and post a problem only once.